Dexamethasone Phosphate
Catalogue number: D298835
Chemical name: Dexamethasone Phosphate
Synonyms: (11β,16α)-9-Fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)pregna-1,4-diene-3,20-dione; 9-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-Phosphate; Betnelan Phosphate; Dexamethasone 21-Dihydrogen Phosphate; Dexamethasone 21-Phosphate; Dexamethasone Orthophosphate; Micromethason; Wymesone
Impurity:
CAS Number: 312-93-6
Possible CAS #: NA
Molecular form.: C₂₂H₃₀FO₈P
Appearance: Off-White to Light Brown Solid
Melting Point: >173°C (dec.)
Mol. Weight: 472.44
Storage: -20˚C Freezer, Under Inert Atmosphere
Solubility: DMSO (Slightly), Methanol (Slightly)
Stability: No Data Available
Category: Drug Analogues, Pharmaceuticals, Intermediates & Fine Chemicals, Steroids,
Boiling Point: No Data Available
Applications: A pro-drug of Dexamethasone (D298800), an anti-inflammatory glucocorticoid. It was found that liposomal DXM-P inhibited both chronic inflammation and joint destruction, whereas free DXM-P failed to prevent joint destruction.
Dangerous Goods Info: NA

References: Kodelja, V., et al.: J. Immunol., 160, 1411 (1998), Metselaar, J., et al.: Arthritis Rheum., 48, 2059 (2003), Buttgereit, F., et al.: Arthritis Rheum., 50, 3408 (2004), Martinez, F., et al.: Front Biosci., 13, 453 (2008)